Bukayo Saka, Dominic Calvert-Lewin and Harvey Barnes have been handed their first senior England call-ups, while Mason Greenwood and Phil Foden have been dropped.
Saka, 19, has featured just three times for Arsenal during this campaign but broke into the first-team and impressed while playing at full-back for the Gunners last season.
Calvert-Lewin, 23, is the Premier League’s joint-leading goalscorer with five, and also scored a hat-trick for the Toffees in Wednesday’s Carabao Cup win over West Ham.
Barnes meanwhile has helped Leicester to the top of the early Premier League table, with the 22-year-old scoring in the Foxes’ win over Burnley.
As expected, England’s head coach, Gareth Southgate has left out Greenwood and Foden after the pair were sent home from Iceland last month for breaching coronavirus protocols by meeting up with two women inside the public areas of the team hotel.
Speaking before Thursday’s squad announcement, Calvert-Lewin said receiving an England call-up would be a dream come true
Manchester United captain Harry Maguire has been recalled, after he was dropped from the last squad following his convictions for assault and attempted bribery in a Greek court, which he has since appealed with the convictions nullified ahead of a full retrial.
Having handed first-time call-ups to six players for last month’s matches, Southgate has a more experienced squad this time, with fit-again Ben Chilwell, Harry Winks and Marcus Rashford returning to the fold.
Liverpool captain Jordan Henderson is also named in the squad despite picking up an injury issue in the Reds’ win over Chelsea.
England have three home games during this international break, including Nations League games against Belgium and Denmark and a friendly against Wales.